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Scientists delay aging of older mice with molecules taken from young mice

A group of scientists, through research published on Cell Metabolism, announces that they have extended the life span of a group of elderly mice by about 16% by inserting into their bodies a special protein contained in the blood of the youngest mice.

This protein, called eNAMPT (extracellular nicotinamide phosphoribosyltransferase), decreases in blood with age (both in rodents and in people and many other animals) which in parallel increases the health problems typical of old age, such as the weight gain, vision problems and all problems related to cognitive declines.

The eNAMPT protein plays an important role in those cells that produce energy in the body but become less and less efficient. Specifically, these proteins produce a sort of “fuel,” called NAD, which the body uses to remain active at all times. As Shin-ichiro Imai, professor of developmental biology at the University of Washington and senior author of the study, explains, this is a remarkable discovery as it could lead to completely new therapeutic pathways to make bodies healthier during the aging.

The same research group, however, has also experimented with another method to keep NAD levels constant with advancing age which sees the use of a molecule called NMN. Also, in this case, the researchers carried out experiments on mice by giving them this molecule by mouth and obtaining more or less the same effects.

This means, according to the researchers themselves, that the methods for ensuring that NAD levels do not decline ruinously with age are different.

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Researchers identify an antiviral drug to combat the bourbon viruse

The Bourbon virus (BOUV) is an RNA virus of the Thogotovirus genus discovered in 2014 when it was identified in the body of a man in Bourbon County, Kansas. It is believed to be spread by ticks (the Kansas man died just after being bitten by ticks so much that he was initially thought to have ehrlichiosis).

After the first case only very few others were discovered, including that of a fifty-eight-year-old Missuori man, also infected by the same virus and who died shortly after.

Now a group of researchers from the Washington University in St. Louis announces, through a study published in PLOS Pathogens, that they have identified an antiviral drug, a treatment that is still only experimental, which seems to cure mice infected with the Bourbon virus.

The drug, called favipiravir, has so far only been approved in Japan for the treatment of one type of flu but not in the United States. The same virus seems to be lethal so that without the use of this drug the mice in the laboratory died in 100% of cases while with the treatment they survived in 100% of the cases. Healing also occurred when the drug was administered to mice only three days after infection when they now had a weakened appearance and had lost a lot of weight.

The favipiravir goes to inhibit a particular protein that the virus uses to survive multiply. At the moment it has not been possible to test the drug on people because the Bourbon virus is very rare. However, the same researchers advise avoiding exposure to ticks as much as possible, even using insect repellents or wearing long dresses that cover the body as much as possible if you are in environments with many ticks.